Leukotriene receptor antagonists: useful in acute asthma?
نویسندگان
چکیده
منابع مشابه
Pathophysiology of the cysteinyl leukotrienes and effects of leukotriene receptor antagonists in asthma.
Cysteinyl leukotrienes, synthesized de novo from cell membrane phospholipids, are proinflammatory mediators that play an important role in the pathophysiology of asthma. These mediators are among the most potent of bronchoconstrictors and cause vasodilation, increased microvascular permeability, exudation of macromolecules and edema. The cysteinyl leukotrienes also have potent chemoattractant p...
متن کاملLeukotriene receptor antagonists and biosynthesis inhibitors: potential breakthrough in asthma therapy.
Cysteinyl leukotrienes are potent bronchoconstrictors, inducers of airway microvascular leakage and oedema, and of mucus secretion, in addition to causing an eosinophilic airway infiltration. Increased urinary excretion of the cysteinyl leukotriene E4 (LTE4) has been demonstrated following allergen challenge and during acute asthma attacks. Strategies for inhibition of cysteinyl leukotriene eff...
متن کاملUse of anti-inflammatory therapy and asthma mortality in Japan.
Asthma treatment guidelines were introduced in Japan in the 1990s, insisting as elsewhere, on the importance of anti-inflammatory therapy. The present study assessed whether use of anti-inflammatory medications was associated with a decrease in asthma mortality in Japan, the first country to use leukotriene receptor antagonists. A population-based ecological study was conducted, spanning the pe...
متن کاملMontelukast: more than a cysteinyl leukotriene receptor antagonist?
The prototype cysteinyl leukotriene receptor antagonist, montelukast, is generally considered to have a niche application in the therapy of exercise- and aspirin-induced asthma. It is also used as add-on therapy in patients whose asthma is poorly controlled with inhaled corticosteroid monotherapy, or with the combination of a long-acting beta(2)-agonist and an inhaled corticosteroid. Recently, ...
متن کاملClinical evaluation of leukotriene receptor antagonists in preventing common cold-like symptoms in bronchial asthma patients.
BACKGROUND We investigated the possibility of preventing common cold-like symptoms as a previously unknown benefit of leukotriene receptor antagonists (LTRAs). METHODS A total of 279 adult patients with bronchial asthma referred to our hospital between June and December 2004 were retrospectively analyzed. Patients were divided into LTRA treated and untreated groups. Frequency of acute exacerb...
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ورودعنوان ژورنال:
- Thorax
دوره 55 4 شماره
صفحات -
تاریخ انتشار 2000